암 관련 연구과제  수행내용

남광우 (2007) : 삼차원 공동 배양 방법을 통한 인체감엽 줄기세포로부터의 골육종의 발생
신상엽 (2007) : 항암 치료 후 발생한 감소성 발열의 임상양상 및 경험적 항생제 치료의 적절성
김봉수 (2007) : 확산 강조 자기공명영상을 이용한 간 국소질의 발견과 간별진단
이창현 (2007) : 제주지역 여성의 유방안 조기검진행위 관련 요인 분석
이상이 (2007) : 교육수준별 2004년 암사망자의 사망전 1년간 의료이용의 차이와 정책적 합의
김우건 (2008) : 정상조직과 암조직의 유전체 문성 측정 연구
장원영 (2008) : 인체 폐암세포의 방사선 조사에 대한 인삼 대사체의 민감 과 및 그 작용 기전 연구
정인호 (2008) : 조기 대장암 환자의 진단과 치료의 지침 마련을 위한 유전자 분석
권정미 (2008) : 갈조류 유래 Fucoidan의 대장암세포(HCT-15) apoptosis 유도 효능 및 작용기전
강영준 (2008) : 제주지역 말기 암환자의 응급 진료 현황과 개선방안

암 관련 연구논문

• Jin Won Hyun ,Sun Hee Yoon, Byung Hak Yoon, Jin Sun Park, Hee Sun Kim, Su Jae Lee, Yun Sil Lee, Ho Jin You, and Myung Hee Chung, 7, 8-dihydro-8-oxo-2'-deoxyguanosine induces G1cell cycle arrest in KG-1, a human acute leukemia cell line, by up-regulating p21 and blocking the Ras to ERK signaling pathway, International Journal of Cancer, 118(2): 302-309 (2006)
• Soo-Hyun Jung, Moon-Sook Woo, So-Young Kim, Won-Ki Kim, Jin-Won Hyun, Eun-Jin Kim, Dong-Hyun Kim, Hee-Sun Kim, Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells. International Journal of Cancer, 118(2): 490-497 (2006)
• Kyoung Ah Kang, Kyoung Hwa Lee, Sungwook Chae, Rui Zhang, Myung Sun Jung, Young Min Ham, Jong Seok Baik, Nam Ho Lee, and Jin Won Hyun, Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation. Journal of Cellular Biochemistry, 97(3): 609-620 (2006)
• Kyoung Ah Kang, Rui Zhang, Kyoung Hwa Lee, Sungwook Chae, Bum Joon Kim, Young Sook Kwak, Jae Woo Park, Nam Ho Lee, and Jin Won Hyun, Protective Effect of Triphlorethol-A from Ecklonia cavaagainst Ionizing Radiation in vitro, Journal of Radiation Research, 47, 61-68 (2006)
• Kim Ja Eun, Hyun Jin Won, Hayakawa Hiroshi, Choi Sung Won, Choi Jin Hee, and Chung Myung Hee, Exogenous 8-oxo-dG is not utilized for nucleotide synthesis but enhances the accumulation of 8-oxo-Gua in DNA through error-prone DNA synthesis, Mutation Research, 596(1-2): 128-136 (2006)
• Seongwon Choi, Hyun Ho Choi, Jun-Ho Choi, Byung-Hak Yoon, Ho Jin You, Jin-Won Hyun, Ja-Eun Kim, Sang-Kyu Ye and Myung-Hee Chung, Inhibitory effect of 8-oxo-7,8-dihydro-2′-deoxyguanosine on the growth of KG-1 myelosarcoma in Balb/c nude mice, Leukemia Research, 30(11):1425-1436 (2006)
• Lee J, Suh C, Park YH, Ko YH., Bang SM, Lee JH, Lee DH, Huh J, Oh SY, Kwon HC, Kim HJ, Lee SI, Kim J H, Park J,Oh SJ, Kim K, Jung CW, Park K, and Kim WS. Extranodal Natural Killer T-Cell Lymphoma, Nasal-Type: A Prognostic Model From a Retrospective Multicenter Study. J Clin Oncol 24(4):612-618 (2006)
• So-Young Kim, Dong-Hyun Kim, Jin-Won Hyun, John W Henson, Hee-Sun Kim, Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells, Biochem Biophys Res Commun. 344:3-8 (2006)
• Kee-In Lee, Youmie Park, Su-Jin Park, Jung-Hwan Hwang, Sung-jin Lee, Gun-Do Kim, Woo-Kyu Park, Sunghou Lee, Daeyoung Jeong, Jae-Yang Kong, Hee-Kyoung Kang and Heeyeong Cho, Naphthofuroquinone derivatives: Inhibition of receptor tyrosine kinases, Bioorganic & Medicinal Chemistry Letters, 16:737-742 (2006)
• Jing Jin, Sanjay Shahi, Hee-Kyoung Kang, Hendrick W. van Veen and Tai-Ping Fan, metabolites of ginsenosides as novel BCRP inhibitors, Biochemical & Biophysical Research Communications, 345:1308-1314 (2006)
• Moon HW, Shin S, Kim HY, Kim YR, Cho HI, Yoon SS, Park S, Kim BK, Chun H, Kim HC, Park CJ, Min YH, Lee DS. Therapeutic use of granulocyte-colony stimulating factor could conceal residual malignant cells in patients with AML1/ETO(+) acute myelogenous leukemia. Leukemia, 20(18):1408-1413 (2006)
• Bang SM, Kim YR, Cho HI, Chi HS, Seo EJ,Park CJ, Yoo SJ, Kim HC, Chun HG, Min HC, Oh BR, Kim TY, Lee JH, Lee DS.Identification of 13q deletion, trisomy 1q, and IgH rearrangement as the most frequent chromosomal changes found in Korean patients with multiple myeloma. Cancer Genetics and Cytogenetics, 168(2):124-132 (2006)
• Lee YK, Kim YR, Min HC, Oh BR, Kim TY, Kim YS, Cho HI, Kim HC, Lee YS, Lee DS.Deletion of any part of the BCR or ABL gene on the derivative chromosome 9 is a poor prognostic marker in chronic myelogenous leukemia. Cancer Genet Cytogenet, 166(1):65-73 (2006)
• YR Kim, YH Chang,DS Lee,JW Park,HC Kim,HK Chun,MS Kim,KJ Han,HI Cho,JH Lee,KH Lee,YS Lee, Korean patients with chronic lymphocytic leukemia show the similar types of chromosomal aberrations as those in Europe and North America. Leukemia Research, 30:695-699 (2006)
• Park HS, Jang KY, Kang MJ. Song KJ, Lee KB, cocytoma of the spinal cord causing paraplegia - a case report. Spinal Cord. 45(2):183-186. (2007)
• Jin SH, Kim DY, Kim H, Jeong IH, Kim MW, Cho YK, Han SU, Multidimensional learning curve in laparoscopy-assisted gastrectomy for early gastric cancer. Surg Endosc. 21(1):28-33. (2007)
• Kyoung Ah Kang, Kyoung Hwa Lee, Jae Woo Park, Nam Ho Lee, Hye Kyung Na, Young Joon Surh, Ho Jin You, Myung hee Chung, and Jin Won Hyun, Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor, FEBS Letters, 581:2000-2008. (2007)
• Kang KA, Zhang R, Piao MJ, Lee KH, Kim BJ, Kim SY, Kim HS, Kim DH, You HJ, and Hyun JW, Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase, Free Radical Research, 41(6):720-729. (2007)
• Kim H, Jee Y, Mun HS, Park JH, Yoon JH, Kim YJ, Lee HS, Hyun JW, Hwang ES, Cha CY, Kook YH, Kim BJ. Characterization of Two Hepatitis B Virus Populations in a Single Korean Hepatocellular Carcinoma Patient with an HBeAg-Negative Serostatus: A Novel X-Gene-Deleted Strain with Inverted Duplication Sequences of Upstream Enhancer Site II. Intervirology, 50(4):273-280 (2007)
• So-Young Kim, Dong-Hyun Kim, Sang-Jun Han, Jin-Won Hyun, Hee-Sun Kim, Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells, Biochemical Pharmacology, 74:1642-1651. (2007)
• Youn, Cha-Kyung; Song, Peter I; Kim, Mi-Hwa Kim, Jin Sook, Hyun, Jin-Won, Choi, Sang-Joon, Yoon, Sang Pil, Chung, Myung-Hee, Chang, In-Youb, You, Ho Jin. Human 8-oxoguanine DNA glycosylase suppresses the oxidative stress-induced apoptosis through a p53-mediated signaling pathway in human fibroblasts. Molecular Cancer Research, 5(10):1083-1098. (2007)
• So-Young Kim, Eun-Jung Lee, Moon-Sook Woo, Ji-Sun Jung, Jin-Won Hyun, Sung-Won Min, Dong-Hyun Kim, Hee-Sun Kim, Inhibition of matrix metalloproteinase-9 gene expression by an isoflavone metabolite, irisolidone in U87MG human astroglioma cells. Biochem Biophys Res Commun. 366(2):493-499. (2008)
• Bae JM, Lee EJ, Guyatt G. Citrus fruit intake and stomach cancer risk: a quantitative systematic review. Gastric Cancer. 11(1):23-32. (2008)
• Mun HS, Lee SA, Jee Y, Kim H, Park JH, Song BC, Yoon JH, Kim YJ, Lee HS, Hyun JW, Hwang ES, Kook YH, Kim BJ. The prevalence of hepatitis B virus preS deletions occurring naturally in Korean patients infected chronically with genotype C. J Med Virol. 80(7):1189-1194. (2008)
• Chang IY, Jin M, Yoon SP, Youn CK, Yoon Y, Moon SP, Hyun JW, Jun JY, You HJ. Senescence-Dependent MutS{alpha} Dysfunction Attenuates Mismatch Repair. Mol Cancer Res. 6(6):978-989.(2008)
• Kim JH, Chang JH, Phee KH, Yoon JH, Kwon SH, Song K, Lee KW, Cho CI, Jeon JH, Kim KS. Cyclooxygenase inhibitors induce apoptosis in sinonasal cancer cells by increased expression of nonsteroidalanti-inflammatory drug-activated gene. International Journal of Cancer. 122(8)1765-1773. (2008)